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Alphagenix are a leading UK TRT provider, offering nationwide coverage on testosterone replacement therapy. We've put together this UK specific TRT guide which should hopefully enable you to understand what your options are.

Feel free to get in touch if you have any questions on UK TRT, our team are always happy to help.

Let's get cracking!

Why would UK men be testosterone deficient?

Testosterone deficiency isn't a UK issue, but there are good reasons why a British man might have lower testosterone levels than his counterpart from another country.

The weather, economy, work/life balance, and culture of This Sceptred Isle all contribute. Let's look at some of the contributing factors;

1. The (In)Famous UK Weather

Vitamin D, which is produced by the skin in response to sunlight, has been shown in multiple studies to have an influence on testosterone levels [1][2].

Vitamin D levels in the UK are so low that the NHS website recommends;

"Government advice is that everyone should consider taking a daily vitamin D supplement during the autumn and winter." 

Even in the balmier months if you use sun screen (as we are all told to do) it may affect the way your skin synthesises the vitamin D[3].

Man in a tent in UK looking utterly miserable in the pouring rain

2. UK Stress Levels

When an individual experiences stress, your body activates the hypothalamic-pituitary-adrenal axis, leading to the release of cortisol from the adrenal glands.  High levels of cortisol can inhibit the production of testosterone.

This is because cortisol and testosterone are made from a common precursor, pregnenolone. When the body is producing high levels of cortisol, it diverts pregnenolone away from the production of testosterone (a phenomenon called the "pregnenolone steal").

Chronic stress can also suppress the release of gonadotropins, which are hormones that stimulate the testes in men.

So why are stress levels higher in the UK? Well, we have been in an economic slump for 15 years. The financial crisis of 2008 was followed by a period of very low growth, then the political turmoil around Brexit followed by the effects of the Covid 19 pandemic.

Now we have rampant inflation and soaring interest rates. We've had a tough ride - whatever you do don't compare notes with an old mate that's lived in Australia for the last 15 years.

Unsurprisingly this has caused considerable and prolonged stress. 79% of working age people report feeling the effects of work related stress (source). A study by The Mental Health Foundation showed that 74% of UK 'overwhelmed or unable to cope' - and this was in 2018 when things were going relatively well (source).

Highly stressed men running across a UK bridge in the rain

3. UK Working Hours & Sleep

Closely related to the previous point, in the UK we work. A lot. In fact according to a study done by the TUC workers in the UK do the longest hours in Europe.

Recent studies from 2022 have shown that as many as 7.5 million people in the UK have under 5 hours sleep a night. Inadequate or disrupted sleep can have detrimental effects on testosterone production and regulation.

  1. 1. Duration: Insufficient sleep (defined as less than the recommended nightly 7-9), has been linked to a lower level of testosterone. Studies have shown a direct link between shorter sleep duration and lower testosterone blood levels in men [4].
  2. 2. Quality: Low sleep quality with frequent awakenings or disturbances, can also negatively impact testosterone levels. Disorders like sleep apnea have been associated with reduced testosterone production [5].
  3. 3. Regulatory: Studies suggest that irregular sleep schedules, such as those of shift workers,  can lead to disturbances in testosterone secretion [6]. UK government stats show that 33% of UK men are involved in shift work, with 16% doing evening shifts and 10% doing night shifts.

The combined effects of long working hours and lack of sleep are another factor which impact UK men and their hormone levels.

Ancient man sitting at a computer

If you are reading this page then the chances are that either you or your husband/partner (around 30% of our visitors are female) are suspected of suffering from testosterone deficiency.

Men with a deficiency will typically have some tell-tale common signs of low testosterone;

  • Fatigue and lack of energy
  • Weight gain, particularly around the abdomen
  • Mood swings and emotional instability
  • Decreased libido and sexual performance issues
  • Difficulty concentrating or remembering things
  • Poor sleep quality or insomnia
  • Loss of muscle mass and strength
  • Hair loss on the body and face

Diagnosing Low Testosterone

Enough of the Doom & Gloom - there is a solution. Alphagenix are a leading provider of testosterone treatment for men, if you are showing signs of low testosterone we can help you enjoy the benefits of TRT.

To diagnose low testosterone, doctors will typically perform a comprehensive evaluation that includes a detailed medical history and physical examination.

A testosterone blood test can be conducted to measure your total testosterone level, as well as other hormones such as LH and FSH, in order to diagnose low testosterone.

Understanding the basics of TRT is essential to making an informed decision about your health. A blood test is crucial in diagnosing low testosterone levels as it measures the amount of testosterone circulating in your bloodstream.

It's important to note that testosterone levels fluctuate throughout the day; hence multiple tests might be required over time before making any conclusions.

  1. Total Testosterone: This test measures both free and bound testosterone in the blood.
  2. Free Testosterone: A more specific measurement focusing on unbound hormone available for use by cells within the body.
  3. Bioavailable Testosterone: Measures both free and albumin-bound hormones which are readily accessible by tissues.
  4. Luteinizing Hormone (LH): Evaluates pituitary gland function related to stimulating production of sex hormones like testosterone.
  5. Follicle Stimulating Hormone (FSH): Assesses overall reproductive health and sperm production.
  6. Prolactin: Helps rule out pituitary gland disorders that may contribute to low testosterone levels.

Testosterone levels naturally fluctuate throughout the day (in a cycle known as circadian rhythm), so multiple tests may be required for an accurate diagnosis.

Low testosterone can lead to more severe health problems like osteoporosis , high cholesterol, raised blood pressure and mental health issues. It is important to get your testosterone levels checked, and for a those results to be reviewed by a doctor.

Once a deficiency is confirmed, one of our UK trained doctors will discuss whether TRT treatment options are appropriate.

TRT Options for UK Patients

There are various types of Testosterone Replacement Therapy (TRT) available in the UK. Each method has its unique advantages, depending on factors such as your lifestyle, age, and medical history. Let's explore some popular TRT options:


Injections are a common form of TRT where testosterone is directly injected into the muscle tissue. They offer quick absorption rates and can be administered every two to three weeks or even up to three months apart with long-acting formulations.

Injections: Pros

  • Injections provide a fast-acting solution with high bioavailability, meaning the body quickly absorbs the testosterone.
  • They require fewer applications compared to other methods.

Injections: Cons

  • Injections can be painful, may cause bruising or swelling at the injection site, and need to be administered by a healthcare professional or yourself after proper training. Around 3-4% of the UK public are also needle phobic[1]

Gels or Creams

Gels or creams applied directly to the skin allow testosterone to be absorbed through the skin surface over time. This method provides a steady release of hormones throughout the day but requires daily application.

Gels/Creams: Pros

  • Gels and creams are easy to apply directly onto the skin daily without needing any medical assistance.
  • They have good absorption rates when applied correctly on specific areas like shoulders or upper arms[2]

Gels/Creams: Cons

  • The drawbacks include potential skin irritation from continuous use, risk of transferring testosterone residue accidentally to family members through contact, and fluctuations in hormone levels throughout the day.
  • It is easy to forget to put the cream on.


Patches worn on specific body parts like upper arms, thighs or abdomen deliver testosterone through transdermal absorption. These patches need replacing every 24 hours and provide consistent hormone levels without requiring injections.

Patches: Pros

  • Patches deliver consistent doses of testosterone over time via transdermal application.
  • They need replacing every 24 hours and provide consistent hormone levels without requiring injections.

Patches: Cons

  • Some people may experience skin irritation or allergic reactions to the adhesive used in patches.
  • They can be visible on the body and might get dislodged during physical activities.

Oral Medications

Taking oral medications taken daily offers convenience for those who do not like needles or applying gels; however, this method may have lower bioavailability compared to other delivery systems due to first-pass metabolism in the liver.

Patches: Pros

  • Taking oral medications is a non-invasive method that's easy to incorporate into daily routines.
  • They offer convenience and privacy compared to other delivery methods.

Patches: Cons

  • Lower bioavailability due to first-pass metabolism[3]
  • Frequent dosing requirements (usually multiple times per day)
  • Again, for men with busy lives and demanding jobs it is really easy to forget and miss a dose.

Implantable Pellets

Sub dermal pellets inserted under local anaesthetic every few months release testosterone slowly over time. This method requires minor surgery and can be an effective long-term solution for those who prefer not to administer treatment daily or weekly.

Pellets: Pros

  • Implantable pellets provide long-lasting treatment with steady hormone release over several months.
  • Requires fewer doctor visits for administration once inserted under local anaesthetic.

Pellets: Cons

  • The invasive nature of pellet insertion.
  • Potential infection risks at implantation site.
  • Difficulty removing pellets if adverse effects occur or dosage adjustments needed.

Nasal Sprays

Nasal sprays administered through a device similar to an asthma inhaler deliver testosterone directly into the bloodstream via nasal mucosa. This method is relatively new, with limited availability in the UK but offers convenience and rapid absorption of hormones.

Nasal Sprays: Pros

  • Nasal sprays offer quick absorption through nasal mucosa, making them an effective option for those who prefer not using injections or transdermal applications.
  • Discreet and portable

Nasal Sprays: Cons

  • Some users report nasal irritation, congestion, sneezing after use which could affect compliance with treatment regimen.
  • The invasive nature of pellet insertion , possible infection risks at implantation site.
  • This method may require more frequent dosing than others..

In order to choose the best TRT option for your needs, it's essential to consult with a qualified healthcare professional experienced in TRT protocols. They will consider factors such as your age, lifestyle, medical history and personal preferences when recommending suitable treatments tailored specifically for you.

Book an appointment with one of our specialist doctors today.

UK TRT : NHS vs Private

So ... how to get TRT in the UK?  When it comes to accessing treatment for low testosterone, men in the UK have two options: the NHS and private healthcare providers. For the majority of the UK population the first port of call is the NHS ... which would be the cheapest of course, but may not be available to you and is not going to be the easiest or fastest route.

National Health Service (NHS)

The NHS provides limited access to Testosterone Replacement Therapy for patients diagnosed with hypogonadism - a condition where insufficient amounts of hormones produced by the testes lead to loss of muscle mass, sexual problems, and reduced quality of life. However, getting TRT through the NHS can be challenging due to strict eligibility criteria and long waiting times. Some key points about receiving TRT through the NHS include:

  • Blood tests: You will need at least two separate blood tests showing low testosterone levels taken on different days before being considered eligible for treatment.
  • Waiting times: The process can take several months from initial consultation to starting treatment due to high demand within the NHS.
  • Costs: If you qualify for TRT under NHS guidelines, your treatment will likely be free or heavily subsidised depending on your income status. We say likely, as with most things NHS there is an element of 'postcode lottery' as different hospital trusts and even individual doctors within those trusts can interpret and apply the NICE guidelines in their own way.

Private Healthcare Providers

In contrast, many people find private healthcare providers offer a quicker and easier route when seeking TRT in the UK. These clinics often have more flexible eligibility criteria than their public counterparts but of course come with costs associated with treatments provided outside government-funded systems. Key aspects of choosing private healthcare providers include:

  • Prescribed TRT : Private clinics can prescribe testosterone treatments, including those not available on the NHS.
  • Speedy access: You may be able to start treatment within weeks rather than months when compared to public healthcare options.
  • Costs: You will need to cover the full cost of your treatment which can vary depending on factors such as dosage and delivery method. However, we've found that this is often less than is initially feared.
  • Approved Clinics: It's essential to choose a registered and regulated clinic that adheres to UK regulations for safe and effective hormone replacement therapy. Always research potential providers thoroughly before committing financially or medically.

Deciding between NHS and private healthcare providers for Testosterone Replacement Therapy in the UK ultimately depends on your personal circumstances, financial situation, and preferred level of convenience.

Book an appointment with one of our specialist doctors today.


In this section, we will touch on some common questions regarding TRT in the UK. For a more detailed look into these topics, please refer to the individual articles discussing them.

The cost of TRT can vary depending on several factors such as the type of treatment, dosage, and frequency. Private TRT clinics typically charge between £145 to £450 per month for a comprehensive testosterone replacement plan which includes medication, blood tests and consultations with medical professionals.

Be warned - we have seen many clinics using pricing models we find uncomfortable. Ensure they are being transparent about all the costs they will charge at the outset.

The old maxim "If it seems too good to be true then it normally is", holds true in the UK TRT market. Unscrupulous operators may drawn you in with a low quote only to add on extras afterwards. Caveat emptor! You can find out more in this detailed article on UK TRT Cost

When administered under proper medical supervision by licensed healthcare providers like those at Alphagenix, TRT is considered safe. However, it's essential to follow your prescribed TRT protocol closely and attend regular check-ups to monitor your hormone levels and overall health status. You can find more safety information from reputable sources such as the British Society for Sexual Medicine (BSSM).

Treatment Plan Development

If your blood tests indicate low testosterone levels, one of our doctors will advise you on the best course of action. Tailored to your results, and your specific preferences or goals.

Our doctors are supplied through BMP Medical Ltd, they are UK trained and registered with the General Medical Council. They continue to work in the NHS, and are experts in the field of male hormone replacement therapy.

An important consideration which many forget, they can also help determine whether an underlying condition is causing your symptoms and recommend appropriate treatment options.

Ongoing Monitoring

We don't just love you and leave you at Alphagenix. Once you start on a program we will be in regular contact to monitor you progression and improvement. We will also monitor your bloods to ensure your prescribed dosages continue to be at the appropriate levels.

The positive effects TRT has can often be transformational: improved relationships, energy and joie de vivre. Alphagenix was set up to help men like you, and hearing these success storiess the most satisfying part of the process for us.

TRT is a legal treatment in the UK for men suffering from low testosterone levels. However, it must be prescribed by a qualified healthcare professional .

You can do this either through the NHS or via a private clinic. Private providers offer tailored dosages, flexible treatment options, and access to advanced diagnostic tools for personalized care.

Testosterone is classified as a Class C drug under the UK Misuse of Drugs Act 1971 so whilst it is not an offence to possess this class of drugs for personal use, it's illegal to supply them without the appropriate license

According to the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK, it's also illegal to purchase prescription-only medicines without a valid prescription. This includes buying them online from unregulated sources. So make sure you go through the proper channels!

Yes, TRT can be prescribed in the UK by both NHS doctors and registered private clinics specializing in hormone replacement therapy.

The prescription depends on an individual’s specific needs, medical history, and blood test results indicating low testosterone levels.

To accurately diagnose low testosterone levels, it is important to consult a qualified healthcare provider who can recommend the appropriate treatments such as Testosterone Replacement Therapy (TRT). The diagnosis process typically involves blood tests or other diagnostic tools to accurately determine your hormone concentrations.

Blood Test Procedures for Detecting Low Hormone Concentrations

A serum testosterone test, which requires a sample of blood typically drawn from an arm vein and is most accurate in the morning when hormone levels are highest, is often employed to measure testosterone concentration. This test requires a small sample of blood, usually drawn from a vein in your arm. It is best performed in the morning when testosterone levels are at their highest. A testosterone level of less than 300 ng/dL is considered to be low, although this range may vary depending on age and individual factors. A healthcare provider may also evaluate hormones associated with testosterone levels, such as LH and FSH, which are critical for regulating its production.

Additional Examinations Necessary for Accurate Diagnosis

  • Physical examination: A thorough physical exam helps assess overall health status and identify any underlying conditions contributing to low testosterone levels.
  • Symptom assessment: Your doctor will ask about symptoms associated with low T-levels, including fatigue, decreased libido, erectile dysfunction, or mood changes.
  • Lifestyle evaluation: Factors such as stress management techniques, exercise habits, or diet could impact hormonal balance; thus addressing these aspects might improve overall well-being without needing medical intervention.

After conducting these examinations, your healthcare provider will determine whether TRT or other treatments are suitable for you. Remember that proper consultation with qualified professionals remains paramount during decision-making processes surrounding available options within this field of medicine.

After assessing the various blood test procedures for detecting low hormone concentrations, it is important to consider additional examinations necessary for accurate diagnosis. Different methods of administering TRT can be compared in order to determine which option best suits an individual's needs and lifestyle.

TRT is typically recommended for men aged 30 and above who are experiencing symptoms of low testosterone.

However, the appropriate age for starting TRT may vary depending on individual factors such as medical history, lifestyle, and severity of symptoms. It's essential to consult with a healthcare professional before beginning any treatment.

Testosterone treatments can be worth it if you're experiencing symptoms of low testosterone that significantly impact your quality of life. Many patients report improvements in energy levels, mood, libido, and muscle mass after undergoing TRT.

However, it's crucial to weigh the potential benefits against costs by discussing with a qualified healthcare provider such as Alphagenix.

Alternatives to TRT include lifestyle changes (such as exercise, diet improvement); natural supplements; stress management techniques (e.g., meditation); and addressing underlying health issues that could contribute to low testosterone levels (like sleep apnea).

Always consult your doctor before trying alternatives.

The number of men receiving testosterone replacement therapy has been increasing over recent years due in part to greater awareness about its benefits. In the United States, an estimated 1-2 million men have received some form of hormone replacement therapy;

The exact number of men on TRT worldwide is unknown.

Yes, we have over 20 clinics in the London area, you'll never be too far away from one. We have a dedicated TRT London page with specific localised information about treatment options.

It depends on the method of delivery and the choice of product. Plus, to an extent it will depend on your test levels and your specific TRT plan. You can find out more here →

Step 3: Our TRT Packages

  • The Aspire plan: £145 per month. This is for patients who are prescribed well-established tablets. On the Aspire plan we conduct routine bloods after 3 months, then every 6 months for the duration of treatment.
  • The Mid-Tier plan: £185 per month . This is for patients who are prescribed certain Injections, Cream or Gel. Routine bloods are tested after 6 weeks, then every 3 months for the duration of treatment.
  • The Alpha plan: £245 per month. This is our most popular plan. This plan is for patients who opt for Premium Injections. Routine bloods are tested at 6 weeks, then every 3 months for duration of treatment.

All packages enjoy the following benefits;

  • ALL scheduled appointments with the doctor.
  • ALL relevant medication.
  • ALL medical equipment required.
  • ALL routine blood tests and clinic visits for blood draws.
  • ALL prescription issuing fees and delivery of medication.
  • PLUS 7-day a week support from our private WhatsApp group including health coaches, nutritional therapist, personal trainer, midlife mentor and high performance mindset coach.
  • PLUS free online video sessions with our certified PT (exercise, nutrition & health coach).
  • PLUS unlimited support calls and admin team support from your designated Account Manager.
  • PLUS monthly newsletter access with company updates, events and offers.
  • PLUS a free monthly subscription to Mental Health App Leafyard

In addition a range of Benefits from our Partners including;

  • 10% discount on private GP services from our partner company AKEALIFE
  • 15% discount on all blue blocker glasses, saunas and biohacks at Bon Charge
  • 15% discount on health tests, products and supplements with DAM Health
  • 10% discount on personalised DNA & Ancestry testing and reports with SelfDecode


  1. Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., ... & Zittermann, A. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(03), 223-225.
  2. Rune Holt et al Vitamin D and sex steroid production in men with normal or impaired Leydig cell function  J Steroid Biochem Mol Biol. 2020 May;199:105589. doi: 10.1016/j.jsbmb.2020.105589. Epub 2020 Jan 15.
  3. David G. Hoel,a Marianne Berwick,b Frank R. de Gruijl,c and Michael F. Holickd. The risks and benefits of sun exposure 2016. Dermatoendocrinol. 2016 Jan-Dec; 8(1): e1248325. Published online 2016 Oct 19. doi: 10.1080/19381980.2016.1248325
  4. Liang Su et al. Effect of partial and total sleep deprivation on serum testosterone in healthy males: a systematic review and meta-analysis 2021 Dec;88:267-273. doi: 10.1016/j.sleep.2021.10.031. Epub 2021 Nov 8.
  5. Sung-Dong Kim, Kyu-Sup. Obstructive Sleep Apnea and Testosterone Deficiency. 2019 Jan; 37(1): 12–18. doi: 10.5534/wjmh.180017
  6. Yasuhiro Ogura et al. Subjective irregular sleep is associated with metabolic syndrome: A cross-sectional study. 2022 Aug; 28: 101844. doi: 10.1016/j.pmedr.2022.101844
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